Our website uses cookies. We use cookies to remember settings and to help provide you with the best experience we can. We also use cookies to continuously improve our website by compiling visitor statistics. Read more about cookies

Choroid plexus tumor (CPT)

A choroid plexus tumor is a tumor that begins in the plexus cells, which line the walls of the brain's ventricles (fluid-filled cavities). This tumor usually occurs at a young age. Some of the children have an underlying abnormality in the DNA of the body cells (Li Fraumeni or SMARC-B1).
Symptoms connected to this disease
Rapid skull growth may occur in young children because their skull is not yet fully developed. Signs of high brain pressure, such as headaches and vomiting, can also figure here. Other complaints include changed eye movement, reduced vision, difficulty walking and occasional epileptic seizures.

How do we make the diagnosis?
An MRI scan of the brain detects the occurrence of a tumor, which is usually located in one of the large ventricles (fluid-filled cavities) of the brain and has a jagged appearance and strong blood flow. Some children can only be diagnosed with certainty after the tumor tissue is examined by means of a biopsy or through surgery (neurosurgical removal). There are various grades of tumors: choroid plexus papilloma, which is the lowest grade tumor and is only local; atypical choroid plexus carcinoma, which is classified as a mid-grade tumor; and choroid plexus carcinoma which is a malignant variant. The patient's spinal fluid is examined and an MRI scan of the spinal cord is done to determine whether there are any signs of metastases.

Treatment of a choroid plexus tumor
The treatment of a choroid plexus tumor differs depending on its subtype. In the event of a plexus papilloma, neurosurgical removal is sufficient in most instances.

In the case of an atypical form or a choroid plexus carcinoma, additional treatment with chemotherapy and, if possible, additional radiotherapy is required. Because these tumors mostly occur in young children, long-term chemotherapy is often required to suppress the tumor cells until their brain can be subjected to radiotherapy.