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MIBG Therapy

MIBG therapy is used to treat certain forms of neuroblastoma. MIBG is a protein that transports radioactive iodine through the blood into neuroblastoma cells, which are subsequently destroyed. By binding radioactive iodine (131-I) to the MIBG protein, the neuroblastoma received targeted radiation therapy without damaging surrounding organs or tissues. So, it is a very localized treatment of the illness. A scan with 123-I-MIBG can demonstrate whether your child's neuroblastoma absorbs MIBG and, therefore, is eligible for MIBG therapy.

Preparations

Many precautions are necessary during the treatment to reduce side effects, also for other people within the environment. Medication must be taken to protect the thyroid gland against the absorption of the radioactive MIBG. Your child's (nursing) specialist will provide instructions about (the duration of) his/her hospital admission. 

 
Treatment

Children with some form of neuroblastoma receive MIBG treatment. In this treatment, radioactive iodine is linked to the protein MIBG. This protein ensures that the radioactive iodine reaches the tumor via the bloodstream and irradiates it on site. During the MIBG treatment, your child is nursed in isolation for five to seven days.

After admission, the radioactivity does not immediately disappear from your child's body. That is why precepts apply at home for a while. 


Aftercare

The treatment has few side effects in the short term and is generally well tolerated. The day that the 131I MIBG is administered, patents occasionally experience nausea. A medication for nausea is standardly provided, and it usually offers sufficient relief. After a few weeks, the bone marrow's production of blood cells can decrease, particularly for the platelets. Minor wounds will take longer to heal and bleeding will not stop as quickly. However, this usually recovers over time. the long-term effects are not known.


Questions?

You can ask a medical or a nursing specialist any questions you may have about the treatment.