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Dr. R. (Raquel) Dávila Fajardo

Kinderradiotherapeut

In het Prinses Máxima Centrum ben ik werkzaam als radiotherapeut oncoloog en draag bij aan de radiotherapeutische zorg rondom kinderen met kanker. In het bijzonder, coördineer ik de brachytherapie behandelingen (inwendige bestraling) bij kinderen. Onderzoek met internationale participatie rondom kinderen met weke delen- en bot sarcomen, niertumoren en extracraniële kiemceltumoren. Zorgen voor de continu implementatie van de meest geavanceerde technieken op het radiotherapie veld.

Kennis en ervaring
Werkervaring   
  • 2015-heden: Staflid afdeling Radiotherapie UMCU & Prinses Máxima Centrum
  • 2010-2015: Staflid afdeling Radiotherapie AMC, Amsterdam
  • 2006-2009: Staflid afdeling Radiotherapie Academische ziekenhuis “Virgen de la Arrixaca”, Murcia (Spanje)

Opleiding
  • 2002-2006: Opleiding tot Radiotherapeut Oncoloog Academische ziekenhuis “Virgen del Rocío”, Sevilla (Spanje)
  • 2000-2002: MIR (Médico Interno Residente): verplichte Spaanse kwalificatie voorafgaande aan de opleiding
  • 1994-2002: Geneeskunde, Faculty of Medicine University of Granada (Spanje)

Promotie
2022: Towards further refinement of radiotherapy stratification in children with nephroblastoma (promotor: Prof. Dr. M. van den Heuvel-Eibrink).

Wetenschappelijke publicaties

  • Perianal/perineal rhabdomyosarcoma: Results of the SIOP MMT 95, Italian RMS 96, and EpSSG RMS 2005 studies. Timothy Rogers, Ilaria Zanetti, Beatrice Coppadoro, Hélène Martelli, Meriel Jenney, Veronique Minard-Colin, Sheila E J Terwisscha van Scheltinga, Clare Skerritt, Raquel Dávila Fajardo, Florent Guérin, Anna Kelsey, Johannes H M Merks, Henry Mandeville, Gabriela Guillén, Heidi Glosli, Federica De Corti, Gianni Bisogno. Pediatr Blood Cancer. 2022 Apr 23;e29739. doi: 10.1002/pbc.29739. PMID: 35460336
  • In transit metastases in children, adolescents and young adults with localized rhabdomyosarcoma of the distal extremities: Analysis of the EpSSG RMS 2005 study. C E J Terwisscha van Scheltinga, M H W A Wijnen, H Martelli, F Guerin, T Rogers, R J Craigie, G Guillén Burrieza, P Dall'Igna, F De Corti, N Smeulders, R R van Rijn, R Dávila Fajardo, H C Mandeville, I Zanetti, B Coppadoro, V Minard-Colin, M Jenney, G Bisogno, M M van Noesel, A F W van der Steeg, J H M Merks. Eur J Surg Oncol. 2022 Mar 12;S0748-7983(22)00123-8. doi: 10.1016/j.ejso.2022.03.001. PMID: 35307252
  • Locoregional control using highly conformal flank target volumes and volumetric-modulated arc therapy in pediatric renal tumors: Results from the Dutch national cohort. Mul J, van Grotel M, Seravalli E, Bosman ME, van Tinteren H, Roy P, Dávila Fajardo R, Tytgat GAM, Mavinkurve-Groothuis AMC, van de Ven CP, Wijnen MHWA, de Krijger RR, Littooij AS, van den Heuvel-Eibrink MM, Janssens GO. Radiother Oncol. 2021 Jun;159:249-254. doi: 10.1016/j.radonc.2021.04.005. PMID: 33845042
  • European guideline for imaging in paediatric and adolescent rhabdomyosarcoma - joint statement by the European Paediatric Soft Tissue Sarcoma Study Group, the Cooperative Weichteilsarkom Studiengruppe and the Oncology Task Force of the European Society of Paediatric Radiology. van Ewijk R, Schoot RA, Sparber-Sauer M, Ter Horst SAJ, Jehanno N, Borgwardt L, de Keizer B, Merks JHM, de Luca A, McHugh K, von Kalle T, Schäfer JF, van Rijn RR; Cooperative Weichteilsarkom Studiengruppe Imaging Group, the European Society of Paediatric Radiology Oncology Task Force and the European Paediatric Soft Tissue Sarcoma Study Group Imaging Committee. Pediatr Radiol. 2021 Sep;51(10):1940-1951. doi: 10.1007/s00247-021-05081-0. Epub 2021 Jun 17. PMID: 34137936 Free PMC article.
  • Dosimetric feasibility of hypofractionation for metastatic bone/bone marrow lesions from paediatric solid tumours. Sophie C Huijskens, Filipa Guerreiro, Mirjam Bosman, Geert O Janssens, Bianca A Hoeben, Raquel Dávila Fajardo, Petra S Kroon, Enrica Seravalli. Radiother Oncol. 2021 Jul;160:166-174. doi: 10.1016/j.radonc.2021.04.020. PMID: 33964326
  • Raphael L Yechieli, Henry C Mandeville, Susan M Hiniker, Valerie Bernier-Chastagner, Susan McGovern, Giovanni Scarzello, Suzanne Wolden, Alison Cameron, John Breneman, Raquel Davila Fajardo, Sarah S Donaldson. Pediatr Blood Cancer. 2021 May;68 Suppl 2:e28254. doi: 10.1002/pbc.28254. PMID: 33818882
  • A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review. Dávila Fajardo R, Pieters BR, Wilde JCH, Heij HA, Chrzan R, Tytgat G, Mavinkurve-Groothuis AMC, Smets A, Kroon PS, Van Damme A, van de Ven KP, de Krijger RR, Lilien MR, Wijnen MH, van den Heuvel-Eibrink MM, Janssens GO. Brachytherapy. 2021 Mar-Apr;20(2):478-484. doi: 10.1016/j.brachy.2020.09.001. Epub 2020 Dec 9. PMID: 33309284
  • The ROCOCO performance scoring system translates dosimetric differences into clinically relevant endpoints: Comparing IMPT to VMAT in an example pilocytic astrocytoma dataset. Lieke in 't Ven, Erik Roelofs, Macarena Cubillos Mesías, Inge Compter, Yvonne L.B. Klaver, Robert Jan Smeenk, Geert O. Janssens, Johannes H.A.M. Kaanders, Raquel Davila Fajardo, Foppe Oldenburger, Dirk de Ruysscher, Esther G.C. Troost, and Daniëlle B.P. Eekersa. Clin Transl Radiat Oncol. 2021 May; 28: 32–38. doi: 10.1016/j.ctro.2021.02.006. PMID: 33748441. PMCID: PMC7966832
  • Outcome of Stage IV Completely Necrotic Wilms Tumour and Local Stage III Treated According to the SIOP 2001 Protocol. Raquel Dávila Fajardo, Rhoikos Furtwängler, Martine van Grotel, Harm van Tinteren, Claudia Pasqualini, Kathy Pritchard-Jones, Reem Al-Saadi, Beatriz de Camargo, Gema L Ramírez Villar, Norbert Graf, Xavier Muracciole, Patrick Melchior, Daniel Saunders, Christian Rübe, Marry M van den Heuvel-Eibrink, Geert O Janssens, Arnauld C Verschuur. Cancers (Basel). 2021 Feb 26;13(5):976. doi: 10.3390/cancers13050976. PMID: 33652659 PMCID: PMC7956604
  • Innovatie door centralisatie voor niertumoren op de kinderleeftijd. Door: prof. dr. M.M. van den Heuvel-Eibrink , prof. dr. R.R. de Krijger , Dr. M. van Grotel , prof. dr. J.H.J. Hoeijmakers , dr. T. Israels , dr. C. Janda , dr. H. van Tinteren , dr. A.M.C. Mavinkurve-Groothuis , dr. G.A.M. Tytgat , drs. A.S. Littooij , dr. R.M. Wösten-van Asperen , drs. R. Davila Fajardo , dr. A. Bos , dr. S. Neggers , dr. M.D. van de Wetering , dr. M. Veening , dr. M. Lilien , dr. F. Schutgens , dr. M.C.J. Jongmans , dr. F.L. Bos , drs. R.L. van Ineveld , dr. A.C. Rios , dr. W.P. Vermeij , dr. P. van der Torre , prof. dr. M. Grootenhuis , P. Roy , C. Kempen-van Overbeek , dr. R.P. Kuiper , dr. G.O. Janssens , drs. C.P. van de Ven , prof. dr. H. Clevers , prof. dr. M.H.W.A. Wijnen , dr. Drost. NED TIJDSCHR ONCOL 2020;17:175-84
  • Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG. Raquel Dávila Fajardo, Marry M van den Heuvel-Eibrink, Harm van Tinteren, Filippo Spreafico, Thomas Acha, Christophe Bergeron, Beatriz de Camargo, Foppe Oldenburger, Christian Rübe, Takaharu Oue, Christian Vokuhl, Ronald R de Krijger, Gordan Vujanic, Neil Sebire, Aurore Coulomb-L'Hermine, Paola Collini, Lorenza Gandola, Kathy Pritchard-Jones, Norbert Graf, Geert O Janssens, Martine van Grotel. Pediatr Blood Cancer. 2020 Feb;67(2):e28039. doi: 10.1002/pbc.28039. PMID: 31625685
  • Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group Bianca A Hoeben, Christian Carrie, Beate Timmermann, Henry C Mandeville, Lorenza Gandola, Karin Dieckmann, Monica Ramos Albiac, Henriette Magelssen, Yasmin Lassen-Ramshad, Barbora Ondrová, Thankamma Ajithkumar, Claire Alapetite, Brian V Balgobind, Stephanie Bolle, Alison L Cameron, Raquel Davila Fajardo, Stefan Dietzsch, Delphine Dumont Lecomte, Marry M van den Heuvel-Eibrink, Rolf D Kortmann, Anne Laprie, Patrick Melchior, Laetitia Padovani, Barbara Rombi, Giovanni Scarzello, Rudolf Schwarz, Klaus Seiersen, Enrica Seravalli, Nicola Thorp, Gillian A Whitfield, Tom Boterberg, Geert O Janssens. Lancet Oncol. 2019 Mar;20(3):e155-e166. doi: 10.1016/S1470-2045(19)30034-8. PMID: 30842059
  • AMORE treatment as salvage treatment in children and young adults with relapsed head-neck rhabdomyosarcoma. Vaarwerk B, Hol MLF, Schoot RA, Breunis WB, de Win MML, Westerveld H, Fajardo RD, Saeed P, van den Brekel MW, Pieters BR, Strackee SD, Smeele LE, Merks JHM. Radiother Oncol. 2019 Feb;131:21-26. doi: 10.1016/j.radonc.2018.10.036. PMID: 30773183
  • Psychosocial well-being of long-term survivors of pediatric head-neck rhabdomyosarcoma. Vaarwerk B, Schoot RA, Maurice-Stam H, Slater O, Hartley B, Saeed P, Gajdosova E, van den Brekel MW, Balm AJM, Hol MLF, van Jaarsveld S, Kremer LCM, Ronckers CM, Mandeville HC, Pieters BR, Gaze MN, Davila Fajardo R, Strackee SD, Dunaway D, Smeele LE, Chisholm JC, Caron HN, Grootenhuis MA, Merks JHM. Pediatr Blood Cancer. 2019 Feb;66(2):e27498. doi: 10.1002/pbc.27498. PMID: 30318743
  • Evaluation of boost irradiation in patients with intermediate-risk stage III Wilms tumour with positive lymph nodes only: results from the SIOP-WT-2001 registry. Raquel Dávila Fajardo, Eva Oldenburger, Christian Rübe, Marta López-Yurda, Kathy Pritchard-Jones, Christophe Bergeron, Norbert Graf, Martine van Grotel, Harm van Tinteren, Daniel Saunders, Marry M van den Heuvel-Eibrink, Geert O Janssens, Foppe Oldenburger. Pediatr Blood Cancer 2018;e27085. PMID: 29693799
  • Re-salvage MRI-guided Focal High-dose-rate Brachytherapy for Locally Recurrent Prostate Cancer. Van Son MJ, Peters M, Moerland MA, Noteboom JL, Eppinga WS, Davila Fajardo R, Lagendijk J, Van der Voort van Zyp JR. 2018 Apr 5;10(4):e2429. doi: 10.7759/cureus.2429. PMID: 29876151
  • Patterns of care survey: Radiotherapy for women with locally advanced cervical cancer. de Boer P, Jürgenliemk-Schulz IM, Westerveld H, de Leeuw AAC, Dávila-Fajardo R, Rasch CRN, Pieters BR, Stalpers LJA. Radiother Oncol. 2017 May;123(2):306-311. doi: 10.1016/j.radonc.2017.04.005. PMID: 28434797
  • Postoperative single-dose interstitial high-dose-rate brachytherapy in therapy-resistant keloids. Hafkamp CJH, Lapid O, Dávila Fajardo R, van de Kar AL, Koedooder C, Stalpers LJ, Pieters BR. 2017 Mar-Apr;16(2):415-420. doi: 10.1016/j.brachy.2016.12.009. Epub 2017 Jan 27. PMID: 28139418
  • Socioeconomic status as an independent risk factor for severe late bowel toxicity after primary radiotherapy for cervical cancer. J J Laan, L R C W van Lonkhuijzen, R M van Os, K M Tytgat, R Dávila Fajardo, B R Pieters, L J A Stalpers, G H Westerveld. Gynecol Oncol. 2017 Dec;147(3):684-689. doi: 10.1016/j.ygyno.2017.10.013PMID: 29074259 DOI: 10.1016/j.ygyno.2017.10.013
  • Interfractional renal and diaphragmatic position variation during radiotherapy in children and adults: is there a difference? Irma W E M van Dijk, Sophie C Huijskens, Rianne de Jong, Jorrit Visser, Raquel Dávila Fajardo, Coen R N Rasch, Tanja Alderliesten, Arjan Bel. Acta Oncol. 2017 Aug;56(8):1065-1071. doi: 10.1080/0284186X.2017.1299936. PMID: 28281356
  • Hearing loss in survivors of childhood head and neck rhabdomyosarcoma: a long-term follow-up study. Schoot RA1, Theunissen EA2, Slater O3, Lopez-Yurda M4, Zuur CL2, Gaze MN3,5, Chang YC3,5, Mandeville HC6, Gains JE3,5, Rajput K7, Pieters BR8, Davila Fajardo R8, Talwar R9, Caron HN1, Balm AJ2, Dreschler WA10, Merks JH1. Clin Otolaryngol. 2016 Jun;41(3):276-83. doi: 10.1111/coa.12527. PMID: 26293165
  • Dávila Fajardo R, Seravalli E, Ruebe C, Bosman M, Saunders D, Wijnen MH, Graf N, van den Heuvel-Eibrink MM, Janssens GO. Improved Target Coverage While Simultaneous-Integrated-Sparing of Kidney and Liver by VMAT in Children Undergoing Whole-Abdomen Irradiation for Wilms Tumour. Pediatric Blood & Cancer 2016;63:S89-S89
  • Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma. Clement SC, Schoot RA, Slater O, Chisholm JC, Abela C, Balm AJM, van den Brekel MW, Breunis WB, Chang YC, Davila Fajardo R, Dunaway D, Gajdosova E, Gaze MN, Gupta S, Hartley B, Kremer LCM, van Lennep M, Levitt GA, Mandeville HC, Pieters BR, Saeed P, Smeele LE, Strackee SD, Ronckers CM, Caron HN, van Santen HM, Merks JHM. Eur J Cancer. 2016 Feb;54:1-10. doi: 10.1016/j.ejca.2015.10.064. Epub 2015 Dec 17. PMID: 26707591
  • A review of the clinical experience in pulsed dose rate brachytherapy. Balgobind BV, Koedooder K, Ordoñez Zúñiga D, Dávila Fajardo R, Rasch CR, Pieters BR. Br J Radiol. 2015;88(1055):20150 doi: 10.1259/bjr.20150310. PMID: 26290399
  • Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. Reineke A Schoot 1, Olga Slater 2, Cécile M Ronckers, Aeilko H Zwinderman, Alfons J M Balm, Benjamin Hartley, Michiel W van den Brekel, Sanjeev Gupta, Peerooz Saeed, Eva Gajdosova, Bradley R Pieters, Mark N Gaze, Henry C Mandeville, Raquel Davila Fajardo, Yen Ch'ing Chang, Jennifer E Gains, Simon D Strackee, David Dunaway, Christopher Abela, Carol Mason, Ludi E Smeele, Julia C Chisholm, Gill A Levitt, Leontien C M Kremer, Martha A Grootenhuis, Heleen Maurice-Stam, Charles A Stiller, Peter Hammond, Huib N Caron, Johannes H M Merks. Eur J Cancer. 2015 Jul;51(11):1424-34. doi: 10.1016/j.ejca.2015.02.010. PMID: 25998323
  • Quantification of renal and diaphragmatic interfractional motion in pediatric image-guided radiation therapy: A multicenter study. Sophie C. Huijskens, Irma W.E.M. van Dijk, Rianne de Jong, Jorrit Visser, Raquel Dávila Fajardo, Cécile M. Ronckers, Geert O.R.J. Janssens, John H. Maduro, Coen R.N. Rasch, Tanja Alderliesten, Arjan Bel. Radiotherapy and Oncology 117 (2015) 425–431. DOI: 10.1016/j.radonc.2015.09.020. PMID: 26433905
  • Differences in respiratory-induced pancreatic tumor motion between 4D treatment planning CT and daily cone beam CT, measured using intratumoral fiducials. Eelco Lens 1, Astrid van der Horst, Petra S Kroon, Jeanin E van Hooft, Raquel Dávila Fajardo, Paul Fockens, Geertjan van Tienhoven, Arjan Bel. Acta Oncol. 2014 Sep;53(9):1257-64. doi: 10.3109/0284186X.2014.905699.
  • Post-operative radiotherapy in patients with early stage cervical cancer. Dávila Fajardo R, van Os R, Buist MR, Uitterhoeve L, Westermann AM, Kenter GG, Rasch CR, Stalpers LJ. Gynecol Oncol. 2014 Jul;134(1):52-9. doi: 10.1016/j.ygyno.2014.04.045. Epub 2014 Apr 29. PMID: 24784874
  • EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer. Dávila Fajardo R, Lekkerkerker SJ, van der Horst A, Lens E, Bergman JJ, Fockens P, Bel A, van Hooft JE. Gastrointest Endosc. 2014 May;79(5):851-5. doi: 10.1016/j.gie.2013.12.027. PMID: 24518121
  • Interfractional position variation of pancreatic tumors quantified using intratumoral fiducial markers and daily cone beam computed tomography. van der Horst A, Wognum S, Dávila Fajardo R, de Jong R, van Hooft JE, Fockens P, van Tienhoven G, Bel A. Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):202-8. doi: 10.1016/j.ijrobp.2013.05.001. Epub 2013 Jun 19. PMID: 23790774

BIG-registratie
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Contactgegevens
Telefoon 088-7567898 / 088-7558800