Kennis & ervaring
Specialisme / subspecialisme: geneesmiddelenonderzoek en myeloide en Down syndroom gerelateerde leukemie.Werkervaring
1996 kinderarts (opgeleid in VUmc)
1996 fellow kinderoncologie in VUmc en LUMC
1999 staflid kinderoncologie VUmc
2005 staflid kinderoncologie Erasmus MC
2014 hoofd kinderoncologie/hemato-oncologie Erasmus MC
2018 Prinses Máxima Centrum
Wetenschappelijk
Opleiding
2003 promotie Towards subgroup-directed therapy in acute myeloid leukemia
2008 Associate professor kinderoncologie Erasmus MC
2015 hoogleraar kinderoncologie met speciale belangstelling voor geneesmiddelenonderzoek, Erasmus MC-Sophia Kinderziekenhuis
In deze jaren begeleidde hij verschillende PhD-studenten:
Co-promotor
- 06-07-2007 Bianca Goemans. New horizons in the characterization and treatment of Acute Myeloid Leukemia.VUmc, Amsterdam.
- 25-05-2011 Brian Balgobind. Unravelling MLL-rearranged pediatric Acute Myeloid Leukemia.Erasmus MC, Rotterdam.
- 16-11-2011 Iris Hollink. Molecular genetic insights in cytogenetically normal pediatric Acute Myeloid Leukemia.Erasmus MC, Rotterdam.
- 21-11-2012 Andrica de Vries. Molecular determinants of JMML and childhood MDS.Erasmus MC, Rotterdam.
- 26-06-2013 Eva Coenen. Genetic heterogeneity of MLL gene rearrangements in pediatric AML: identification of new markers with biological and clinical relevance.Erasmus MC, Rotterdam.
- 06-11-2013 Marjolein Blink. Clinical Relevance of Genetic Alterations in Acute Myeloid Leukemia in Children with Down syndrome.Erasmus MC, Rotterdam.
- 02-07-2014 Trudy Buitenkamp. Clinical Relevance of Genetic Alterations in Acute Lymphoblastic Leukemia in Children with Down syndrome.Erasmus MC, Rotterdam.
- 17-06-2015 Jenny Katsman-Kuipers. Altered gene and MiRNA regulation in pediatric acute myeloid leukemia.Erasmus MC, Rotterdam.
Promotor
- 14-06-2016 Jasmijn de Rooij. Molecular genetic aberrations and their prognostic relevance in pediatric acute myeloid leukemia. Erasmus MC, Rotterdam.
- 11-01-2022 Sebastiaan Sassen. Towards precision dosing in pediatric oncology. Erasmus MC, Rotterdam.
- 27-09-2022 Priscilla Wander. Identification of therapeutic options for high-risk pediatric acute leukemia: a high-throughput screening approach. Erasmus MC, Rotterdam.
- 13-10-2022 Laura Nijstad. Pharmacological dose optimization in children with cancer,2e promotor (1e promotor Alwin Huitema), UMCU, Utrecht.
- 09-11-2022 Sanne Noort. Pediatric AML, a heterogeneous fusion-gene driven disease. Erasmus MC, Rotterdam.
- 21-12-2022 Eline Zijtregtop. Clinical Applicability of Biomarkers in Diagnosis and Treatment of Pediatric Hodgkin Lymphoma.Erasmus MC, Rotterdam.
- 12-09-2023 Erica Brivio. Pediatric leukemia: new treatment opportunities and supportive care studies. Erasmus MC, Rotterdam.
- Xx-xx-2023 Eline Bertrums. The clonal dynamics underlying the genesis and regression of myeloid disorders. Erasmus MC, Rotterdam.
Wetenschappelijke publicaties
Mijn publicaties op pubmed lees je hier.
- Gore L, Kearns PR, de Martino Lee ML, De Souza CA, Bertrand Y, Hijiya N, Stork LC, Chung NG, Cardos RC, Saikia T, Fagioli F, Seo JJ, Landman-Parker J, Lancaster D, Place AE, Rabin KR, Sacchi M, Swanink R, Zwaan CM. Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial. J Clin Oncol. 2018 May 1;36(13):1330-1338-
- Bolouri H, Farrar JE, Triche T Jr, Ries RE, Lim EL, Alonzo TA, Ma Y, Moore R, Mungall AJ, Marra MA, Zhang J, Ma X, Liu Y, Liu Y, Auvil JMG, Davidsen TM, Gesuwan P, Hermida LC, Salhia B, Capone S, Ramsingh G, Zwaan CM, Noort S, Piccolo SR, Kolb EA, Gamis AS, Smith MA, Gerhard DS, Meshinchi S. The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med. 2018:Jan 24(1):103-112
- Moreno L, DuBois SG, Glade Bender J, Mauguen A, Bird N, Buenger V, Casanova M, Doz F, Fox E, Gore L, Hawkins DS, Izraeli S, Jones DTW, Kearns PR, Molenaar JJ, Nysom K, Pfister S, Reaman G, Smith M, Weigel B, Vassal G, Zwaan CM, Paoletti X, Iasonos A, Pearson ADJ; Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents. J Clin Oncol. 2023: Published online: April 4, 2023
- De Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA. Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet. 2017 Mar;49(3):451-456
- Zwaan CM, Kolb EA, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R, De Bont ES, De Moerloose B, Dworzak M, Gibson BE, Hasle H, Leverger G, Locatelli F, Ragu C, Ribeiro RC, Rizzari C, Rubnitz JE, Smith OP, Sung L, Tomizawa D, van den Heuvel-Eibrink MM, Creutzig U, Kaspers GJ. Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia. J Clin Oncol. 2015 Sep 20;33(27):2949-62.
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29025124501
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